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This combined systemic, direct hepatic, anti-addictive, and even anti-viral action establishes GLP-1RAs as a powerful, novel approach to reduce the cumulative toxic insults driving SLD progression across multiple etiologies

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Its approval in global markets and pending US approval underscore the growing need for therapies that match the complexity of real-world patients

Medical management Glucagon-like peptide 1 agonist Long-acting glucagon-like peptide 1 (GLP-1) agonists such as semaglutide, liraglutide, and tirzepatide are currently available in the U.S

Schenker, N