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However, 0.5 mg/kg B.W

[the late Bon Scott, AC/DC's first singer]

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Fluctuations in estradiol and progesterone during the menstrual cycle likely influences smoking and anxiety (and their comorbidity) through various neurobiological processes implicated in drug reinforcement (via dopamine activation) (27), which has received most attention in the addiction literature, and emotion dysregulation (via serotonin, hypothalamic pituitary adrenal (HPA) axis, gamma-hydroxy-butyric acid (GABA) (28, 29)), which has received attention in the anxiety psychopathology literature