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On average, it is estimated that 10 puffs of a standard 18mg/ml e-liquid are roughly equivalent to one cigarette

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1 Just as you wouldnt wind down with an espresso before bed, a cigarette prior to going to sleep actually introduces a powerful stimulus into the bloodstream which can cause insomnia and/or sleep-disordered breathing, rather than relaxing your body

doi: 10.1016/j.saa.2006.10.034

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