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An updated meta-analysis of nicotine preloading for smoking cessation: investigating mediators of the effect

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Additives also have an effect on product palatability and pharmacologic properties (Box 1) in ways that make cigarettes less harsh and more pleasant to the user [3],[151],[152], leading to higher initiation and lower cessation and, so, more tobacco use and tobacco-induced disease [4],[19]

Acknowledgements The authors acknowledge support from the laboratories of Kathleen Caron, Margeaux Marbrey, Claire Doerschuk, and Susan Murphy and from Carolyn Suitt and the CGIBD Histology Core at the University of North Carolina

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