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And, also like wines, different blends have different life-expectancies before they go "over the hill." Biological and chemical processes begin to take place as soon as a tobacco is tinned, and the changes can be dramatic, depending on the blend itself, how long its left to sit, and the conditions under which its aged

In all three cohorts, participants completed validated questionnaires every two years that captured information on disease diagnosis, disease risk factors, drug use, and lifestyle characteristics, with follow-up rates exceeding 90%