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Your body begins to rely on the nicotine to induce good feelings, and if it does not get the nicotine, you become: Irritable Anxious Sad Distracted Tired or sluggish Nicotine can cause even more serious side effects in individuals 25 and under, including: It can impair your memory and attention

What that means in practice is that flavor doesn't drift as the device ages

J Toxicol Environ Health A 72(1112):698705

(2011) Exposure to parental and sibling smoking and the risk of smoking uptake in childhood and adolescence: a systematic review and meta-analysis