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The upregulated proteins were significantly enriched in metabolic pathways such as Starch and sucrose metabolism (map00500) and Amino sugar and nucleotide sugar metabolism (map00520)

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Early casecontrol studies observed that smokers had approximately twice the risk of developing bladder cancer compared to non-smokers, and a large prospective cohort study in Australia further reported that smoking accounted for nearly 50% of the total bladder cancer burden

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