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Materials and methods Study design We selected compounds with high oral bioavailability (OB) and drug-likeness (DL) from the Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), setting our thresholds at OB 30% and DL 0.18

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Hence, a prospective cohort study has no issues in identifying an exposure-response link, but caution should be taken when generalizing the findings to the total population

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