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Interestingly, a positive correlation between ACE2 and DPP4 is reported recently in several normal tissues [312]

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[57] The activation of nAChRs by nicotine boosts the release of neurotransmitters, while altering the function of some of themsuch as norepinephrine, dopamine, serotonin (5-HT), and endogenous opioid peptidesthus modifying the action of the peripheral nervous system and causing cigarette addiction

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