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As one review stated, Nicotine is the addictive chemical in tobacco smoke, but its involvement in smoking-related harm (outside pregnancy) is very small, if any, compared to cigarette smoking. Another systematic review pointed out that nicotine can have a variety of potential health effects, from raising ones cardiovascular risk to causing birth defects in pregnant women

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Limitations The overview approach we used for interventions other than e-cigarettes comes with limitations, as we relied on what was reported in the Cochrane systematic reviews