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PMC 2633544

Ideal chelating agents should exhibit a higher affinity for the metal toxicant being chelated, exhibit low toxicity itself, possess rapid excretion and through metal toxicant elimination, be ideally water soluble, cell membrane permeable, use an oral route of administration, undergo minimal metabolism and possess the ability to chelate with naturally occurring chelating groups in the biological system concerned

De Bleser PJ, Xu G, Rombouts K, Rogiers V, Geerts A (1999) Glutathione levels discriminate between oxidative stress and transforming growth factor- signaling in activated rat hepatic stellate cells