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Naturally produced by the body, its most concentrated in the liver, where it performs several essential tasks: Neutralizing free radicals and oxidative stress Assisting in detoxification pathways Regulating immune response Aiding in cell repair and regeneration As we age or face chronic stress, poor diets, pollution, or alcohol use our natural glutathione levels decline

For example, a small number of subjects reported the following mild side effects in the course of a four-week glutathione study at the dose of 1g/day [13]: Flatulence Loose stools Flushing Weight gain In a more specialized study involving cystic fibrosis patients and much higher glutathione doses, some of the patients reported tightness in the torso, diarrhea, and fever-like symptoms [14]

SIRT1 induces the circadian transcription of core clock genes, such as Cry1, Per2, Ror, and Bmal1 via either rhythmically deacetylating BMAL1 or PER2