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Glossary COPD chronic obstructive pulmonary disease WHO World Health Organization AMs alveolar macrophages BALF bronchoalveolar lavage fluid M1 classically activated M2 alternatively activated OXPHOS oxidative phosphorylation ROS reactive oxygen species TCA tricarboxylic acid TR- tissue-resident MO- monocyte-derived MDMs monocyte-derived macrophages BMDMs bone marrow-derived macrophages LPS lipopolysaccharide IFN- interferon- iNOS inducible nitric oxide synthase IL interleukin TNF- tumor necrosis factor GM-CSF granulocyte-macrophage colony-stimulating factor CXCL9/MIG chemokine (C-X-C motif) ligand 9 CCL2/MCP-1 chemokine (C-C motif) ligand 2 NF-B nuclear factor kappa-B PPAR peroxisome proliferator-activated receptor Wnt5a Wnt family member 5a TGF- transforming growth factor- Arg1 arginase 1 MMP matrix metalloproteinase PPP pentose phosphate pathway FA fatty acid FAO fatty acid oxidation CARKL carbohydrate kinase-like protein HIF1 hypoxia-inducible factor 1-alpha PGC-1 PPAR-coactivator protein 1 TIPE2 TNF--induced protein 8-like 2 CSE cigarette smoke extracts mtROS mitochondrial reactive oxygen species ETC electron transfer chain RET reverse electron transport mtDNA mitochondrial DNA NOX NADPH oxidase SIRT1 sirtuin 1 HMGB1 high-mobility group box 1 TLR2 Toll-like receptor 2 Prxs Peroxiredoxins NAC N-acetylcysteine MIF migration inhibitory factor MKK3 MAP kinase kinase 3 ECAR extracellular acidification rate GPD2 glycerol-3-phosphate dehydrogenase 2 FAS fatty acid synthesis PDH pyruvate dehydrogenase complex SREBP1 sterol regulatory element-binding protein 1 DNL de novo lipogenesis S1P sphingosine-1-phosphate GSH Glutathione SCFA short-chain fatty acids RSV respiratory syncytial virus IAA indole-3-acetic acid miRNAs Micro-RNAs Mtb Mycobacterium tuberculosis DMF Dimethyl fumaric acid GAPDH glyceraldehyde-3-phosphate dehydrogenase 2DG 2-Deoxy-D-glucose References 1 ChristensonSASmithBMBafadhelMPutchaN

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