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doi: 10.1007/s00125-005-0126-y 199 LincoffAMBrown-FrandsenKColhounHMDeanfieldJEmersonSSEsbjergSet al

Insulin and Norepinephrine Regulate Ghrelin Secretion from a Rat Primary Stomach Cell Culture

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Although many of these studies have based their findings on peripheral markers of abnormal metabolism, many studies have documented some of these same abnormalities in the brain of individuals with ASD, including mitochondrial dysfunction and oxidative stress (30) and one study has demonstrated a link between oxidative stress, inflammation, and mitochondrial dysfunction in the brain of individuals with ASD (23)

Our data provide some insights into factors influencing treatment response, but developing robust biomarkers may be necessary for precision medicine approaches at the individual level