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Research Square Preprint2021 May

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MD simulations also identified a natural compound schisandrin B (Sch B) that specifically bound to the ligand-binding domain of PXR, induced conformational changes and disrupted the PARP1PXR interaction interface, thus suppressed the ribosylation

Bovine albumin (Sigma-Aldrich, Poland) was used to prepare a standard curve [7]

Since DHA is known to increase the synthesis of BDNF in the brain 26,27 , and since there is a bidirectional transport of BDNF through the blood brain barrier (BBB) 28 , we investigated whether the increase in plasma BDNF can be used as a functional biomarker for the increase in brain DHA