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Phase II neutralizes them by covalently attaching a conjugation group (glucuronic acid, glutathione, sulfate, acetyl, methyl, or amino acid) that increases polarity, reduces reactivity, and enables transport into bile or urine

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As glutathione levels fade, so do its effects

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10.1093/nar/gky1120 8 BurgessS.BowdenJ.FallT.IngelssonE.ThompsonS