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It is a monitoring framework, not a results promise

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Lephart have no conflicts of interest to declare

Nevertheless, in a mediation analysis of the effects of liraglutide 1.8 mg in the LEADER trial [32], the CVD risk reduction was associated mainly with HbA 1c reductions, whereas contributions from other measured parameters (except a weak contribution from improvements in the urine albumin-to-creatinine ratio) were small