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Reference Hayman MME et al

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A meta-analysis showed that MTS is associated with pathogenic variants in the mismatch repair genes in the following frequencies: MLH1 (15%), MSH2 (62%), MSH6 (8%), and PMS2 (1%).[11-17] In a study of 36 sebaceous lesions that included sebaceous carcinomas, sebaceous adenomas, and sebaceomas, 38.9% of lesions were missing one or more mismatch repair proteins on immunohistochemistry (IHC).[18] Of the ten individuals with absent staining of one or more mismatch repair proteins, five had genetic testing that confirmed a diagnosis of Lynch syndrome

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