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At physiological levels, infusion of GIP does not stimulate GLP-1 secretion in vagotomized rats compared to the peak observed at 10 min in the sham controls (Rocca and Brubaker, 1999)

Wegovy (semaglutide 2.4mg) is a GLP-1 receptor agonist licensed by the MHRA for weight management, but it must be used alongside dietary modification, not as a replacement for healthy eating

10.1016/j.phymed.2018.09.212 63 KhanM

Weight loss without parallel changes in nutrition, sleep, movement, and stress management tends to be less durable

Both Novo and Lilly have slashed prices for people who pay cash because their insurance plan doesn't cover GLP-1s to reduce obesity