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The figure connects the activation of GLP-1R to downstream pathways (cAMP/PKA, Epac/PI3K/Akt, AMPK/SIRT1, ERK/MAPK) that regulate mitochondrial function, autophagy, proteostasis, and stress response, all of which collectively influence the hallmarks of aging to improve both cellular and systemic resilience

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(B) GLP-1 receptor agonists increase relative risk, but absolute risk is low averaging 27 cases per 10,000 patients each year

Effect of LALPVYN pretreatment on ROS of H 2 O 2 -mediated oxidative injured HepG2 cells Studies have shown that excess ROS causes the oxidation of proteins and lipids, which in turn leads to the disruption of nuclear DNA and mitochondrial integrity and ultimately, to cell death (39, 46)

Even so, the FDA noted that it could not rule out a small risk because isolated cases of suicidal thoughts or actions have been reported in people using GLP-1 drugs