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The DIX domains and axin, GSK-3, and Disheveled (Dvl) are key players in the -catenin destruction complex, thereby determining the interaction of -catenin with the transcription factor TCF and, thus, the expression of the Wnt target genes ( The -catenin/E-cadherin complex is the key component of adherens junctions (AJs), which stabilizes cellcell junctions, provides cellcell adhesion, and binds -catenin with the actin cytoskeleton ( Therefore, dysfunctions in AJs and TJs may cause aberrations in cellcell adhesion and the actin cytoskeleton ( Pseudomonas aeruginosa , one of the bacteria involved in CFAS-D ( Importantly, our MCODE analysis revealed another highly significant molecular complex in the CFAS-D network comprising the hydrogen peroxide metabolic process, amine oxidase reactions, and the -catenin degradation pathway, indicating that interactions between those factors are involved
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