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(3) suppression of matrix metalloproteinases (MMPs), particularly MMP-3 and MMP-13, which are crucial mediators of cartilage degradation and joint inflammation [99,100,101]

His weight is optimal and he is showing great muscle structure

J Clin Endocrinol Metab 2014;99:200817

Other gastrointestinal effects of Wegovy that patients should be aware of include: Nausea and vomiting (particularly during dose escalation), which may affect the ability to take or retain oral medications Reduced appetite , which might influence the timing of medication taken with food Gastrointestinal discomfort , which could be confused with medication side effects If you experience persistent nausea whilst taking Wegovy, taking paracetamol with a small amount of food may help with tolerability