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Although emerging therapies such as glucagon-like peptide-1 (GLP-1) analogues (e.g., semaglutide) and dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonists (e.g., tirzepatide) have received clinical approval for obesity management, substantial demand persists for alternative or adjunctive therapies employing distinct mechanisms
I do not love the reality of it most days
In the United States, prescribing information for all medications licensed for obesity that act on the CNS, including the GLP-1RAs liraglutide 3 mg (Saxenda) and semaglutide 2.4 mg (Wegovy), must include the recommendation of monitoring for depression and suicidal ideation 231
And when weight increased, when hunger changed, when the body felt unfamiliarthey were told to try harder
In the end, at least in the current regulatory environment, the big decisions will be made by each individual
