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Pharmacokinetic differences were again excluded (Fig

Lysosomal dysfunction and neurodegeneration Lysosomal dysfunction is a prominent pathological hallmark of NDDs

None of these studies revealed any significant differences between the ASD group and the healthy control group, although it is appropriate to be cautious in interpreting negative findings

In doing so, we highlight current gaps in our knowledge regarding MM progression, and propose important future research directions, includes studying the genetic evolution trajectory of MM from benign precursor lesions and evaluating new targeting strategies specifically for MM, such as targeting CDK4, SF3B1 or PARP, either as single agent or in combinations with ICBs

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