Whereas first-generation vaccines rely mainly on spike, there is strong evidence that adaptive immunity to nonspike antigens contributes to protection from infection and disease in natural infection
I work with patients both on and off GLP-1 medications to support the underlying physiology not just the symptoms
Versus bariatric surgery (sleeve, Roux-en-Y bypass) : the most strategically interesting comparison
Among GLP-1 medications specifically, semaglutide has one of the longest half-lives: Exenatide (Byetta): approximately 2.4 hours, requires twice-daily injections Liraglutide (Saxenda, Victoza): approximately 13 hours, requires once-daily injections Dulaglutide (Trulicity): approximately 5 days, requires once-weekly injections Semaglutide (Ozempic, Wegovy): approximately 7 days, requires once-weekly injections Tirzepatide (Mounjaro, Zepbound): approximately 5 days, requires once-weekly injections Semaglutides seven-day half-life ties it with dulaglutide for the longest among currently approved GLP-1 medications
Pinchera A, Wiersinga WM, Glinoer D, Kendall-Taylor P, Koornneef L, Marcocci C, Schleusener H, Romaldini J, Niepominiscze F, Solomon D, Garrity J, Gorman CA 1992 Classification of eye changes of Graves disease