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Moreover, MSM has been suggested to act as a direct free radical scavenger, a mechanism that could also be involved in its antioxidant properties [14]

Furthermore, Epithalon is believed to act as an antioxidant, reducing lipid oxidation and reactive oxygen species while normalizing T cell function

The mechanism is thought to involve direct melanocyte stimulation via MC1R, promoting melanocyte proliferation and migration into depigmented areas while UV-B provides the complementary stimulus for melanocyte activation

Whilst mutations of the MC4R are a rare genetic cause of obesity, the treatment of two people with POMC deficiency with the MC4R agonist setmelanotide previously resulted in massive weight loss of 51.0 kg and 20.5 kg over 42 and 12 weeks respectively [97], highlighting the potential of this mechanism to support weight loss in obesity