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From a safety or side effect profile, I think the bigger concern is the side effect profile. The GLP-1s do have nausea and vomiting or gastrointestinal side effects, he said, which are usually more pronounced in the first month or two of therapy

Semaglutide carries a boxed warning for thyroid C-cell tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)