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10.4103/1673-5374.389626 14 DodsR

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Data availability All data generated or analyzed during this study are included in this published article [and its Supplementary Information files]

The construction of the network graph was facilitated using the igraph and ggraph packages (B) Venn diagram of the common downregulated DEGs among GSE14668, GSE96851 and ferroptosis-related genes (C) GO enrichment analysis and KEGG pathway analysis of upregulated ferroptosis-related DEGs (FRGs) (D) GO enrichment analysis and KEGG pathway analysis of downregulated FRGs (E) A network graph of the 55 FRGs (F) In Cytoscape, the maximum connectivity clustering (MCC) algorithm was used to identify the top 10 highly connected ferroptosis-related genes (G) Expression levels of the top ten ferroptosis-related gene biomarkers between the patients with HBV-ALF and normal controls in GSE14668 (H) Expression levels of the top ten ferroptosis-related gene biomarkers for patients with HBV-ALF and normal controls in GSE96851

Six of these studies reported the combination therapy as an add-on treatment