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Collectively, these data show that DMF constitutes an attractive compound for the pharmaceutical industry for drug repurposing in other neurodegenerative diseases ( TABLE 1 DMFs ability to alleviate pathological hallmarks of AD, PD and ALS in pre-clinical models in the context of Nrf2 activation

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On the fourth day, 1 mg ml of l-(4, 5-Dimethylthiazol-2-yl) 3, 5-diphenyIformazan reagent (MTT, Sigma- Aldrich) prepared in PBS was added to the cells and incubated for 4 h